Dr. Ashok Kumar Patel
Kusuma School of Biological Sciences,
Room No. 306, Block1A
Indian Institute Of Technology Delhi
Hauz Khas, New Delhi – 110016, India.
About: Ashok K. Patel
Ashok’s early training at BSc. and MSc. Level was in Physics at BHU, Varanasi, India. He joined the Molecular Biology Unit, Institute of Medical Sciences, BHU, Varanasi for Ph.D. with Prof. J.V. Medicherla where he carried out structural and biophysical studies of proteins from natural source. His active interest in proteins led him to get training from Prof. David W. Rice, University of Sheffield, UK (2007); Prof B.W. Dijkstra, University of Groningen, The Netherlands (2008) and Prof. Petri Kursula at University of Oulu, Finland (2009) on the travel fellowship by Boehringer Ingelheim Fonds (BIF) Germany. He worked as postdoc fellow with Prof. Gregory Bowman in Johns Hopkins University, USA during 2009-2013 where he worked on chromatin remodeling. Currently He is working as an Assistant Professor in Kusuma school of Biological Sciences, IIT Delhi.
Expertise and interest: Biomolecular X-Ray Crystallography, Molecular and Structural Virology, Structure & function study of Chikungunya and Dengue Virus, host-pathogen interaction, molecular intervention, Chromatin Remodeling and diseases etc.
1) SBL-201: 3-0-0 credit : “High Dimensional Biology”
2) SBL-100: 3-0-2- credit: “Introductory Biology for Engineers”
3) SBL-713: 3-0-0 credit : “Introduction to Structural Biology”
4) SBL720: 3-0-0 credit: “Genome and Healthcare”
5) SBL721: 3-0-0 Credit: “Techniques In Bio-molecular Interactions”
6) 1-0-0 credit: “Stem Cells”
High Dimensional Biology: lecture slides
1. Chromatin and diseases, Epigenetics, Chromatin remodeling, Transcriptional factors, Kinases, cancer, DNA damage repair, histone modifications.
Chromatin remodeling Project:
The packaging of DNA into nucleosomes and into chromatin fibers can take a range of functionally distinct forms. The regulation of chromatin environment is achieved by a complex web of factors by enzymes which add and remove covalent modifications to histone proteins (resulting in various patterns of methylation, acetylation, phosphorylation, ubiquitination, etc) and by ATP-dependent chromatin remodelers that assemble, move, and evict histones from DNA. By chemically modifying histone proteins and changing histone positioning on DNA, these factors create particular chromatin environments required for gene expression and silencing. Disruption of these factors cause severe imbalances in gene expression, and cancer. Our lab is trying to understand the chromodomain helicase DNA-binding (CHD) family of ATP-dependent chromatin remodelers, which has emerged as important regulators of cellular differentiation. CHD proteins are thought to function in the nucleus via binding to DNA and regulating gene transcription. CHD7, a member of the CHD family, encodes a protein mutated in human CHARGE syndrome, a multiple anomaly disorder that affects hearing, vision, and cardiac, craniofacial, and nervous system development. Our strategy is to obtain structural information of CHD7 using X-ray crystallography and cryoEM to understand the process of chromatin remodeling. The structural understanding of chromatin remodelers may allow identifying targets, biomarkers and diagnostic tools relevant for biomedical application for novel therapeutics.
2. Structural investigation in Chikungunya virus and Dengue virus, host-pathogen interaction studies, molecular intervention against Dengue and Chikungunya, antivirals from natural sources etc.