james gomes


Metabolic Regime Control for Production of Biotherapeutics, SERB, DST, PI

Continuous Processing for Production of Biotech Therapeutics (under UAY scheme), MHRD, Co-PI

Centre of Excellence for Bio-pharmaceutical Technology, DBT, Co-PI


Peer Reviewed Journals

  1. Aditya K. Padhi, James Gomes, A molecular dynamics based investigation reveals the role of rare Ribonuclease 4 variants in amyotrophic lateral sclerosis susceptibility, Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 813, 1-12 (2019) https://doi.org/10.1016/j.mrfmmm.2018.11.002
  2. Priyanka, Souhardya Roy, Viki Chopda, James Gomes*, Anurag S. Rathore*, Comparison and implementation of different control strategies for improving production of rHSA using Pichia pastoris, J Biotechnol accepted Dec 2018
  3. Priyam Narain, James Gomes, Rohit Bhatia, Inder Singh, Perumal Vivekanandan, C9orf72 hexanucleotide repeat expansions and Ataxin 2 intermediate length repeat expansions in Indian patients with amyotrophic lateral sclerosis, Neurobiology of Aging, https://doi.org/10.1016/j.neurobiolaging.2017.04.011
  4. B. Chatterjee, B. Banoth, T. Mukherjee, N. Taye, B. Vijayaragavan, S. Chattopadhyay, J. Gomes, S. Basak, Late-phase synthesis of IkBa insulates the TLR4-activated canonical NF-kB pathway from noncanonical NF-kB signaling in macrophages. Sci. Signal. 9, ra120 (2016). PMID
  5. V. R. Chopda, M. Pathak, J. Batra, J. Gomes, and A. S. Rathore (2016) Enabler for Process Analytical Technology Implementation in Pichia pastoris Fermentation: Fluorescence Based Soft Sensors for Rapid Quantitation of Product Titer, Engineering in Life Sciences, in print.
  6. P Kathiresan, J Kumar, V Chopda, S Jain, M Banerjee, AS Rathore, J. Gomes (2016) An Input-Output Linearizing Controller for Producing Angiogenin from E. coli, in Microbes in the Spotlight: Recent Progress in the Understanding of Beneficial and Harmful Microorganisms, BrownWalker Press, 379-384.
  7. A. S. Rathore, V. R. Chopda, J. Gomes (2016) Knowledge Management in a Waste based Biorefinery in the QbD Paradigm, Bioresource Technology 215, 63-75.
  8. V. R. Chopda, J. Gomes, and A. S. Rathore (2016) Bridging the gap between PAT concepts and implementation: An integrated software platform for fermentation,Biotechnology Journal11, 164-171.
  9. H Kumar, F Frischknecht, GR Mair, J Gomes (2015) In silico identification of genetically attenuated vaccine candidate genes for Plasmodium liver stage Infection, Genetics and Evolution 36, 72-81. PMID
  10. VR Chopda, AS Rathore, J Gomes (2015) Maximizing biomass concentration in baker’s yeast process by using a decoupled geometric controller for substrate and dissolved oxygen, Bioresource technology 196, 160-168.
  11. J Gomes, VR Chopda, AS Rathore (2015) Integrating systems analysis and control for implementing process analytical technology in bioprocess development, Journal of Chemical Technology and Biotechnology 90 (4), 583-589.
  12. SV Vasaikar, B Jayaram, J Gomes (2015) Rapid computation and interpretation of Boolean attractors in biological networks, Journal of Complex Networks 3 (1), 147-157.
  13. SV Vasaikar, S Ghosh, P Narain, A Basu, J Gomes (2015) HSP70 mediates survival in apoptotic cells—Boolean network prediction and experimental validation, Frontiers in cellular neuroscience, 9: 319. doi:10.1093/comnet/CNU011.
  14. AK Padhi, K Banerjee, J Gomes, M Banerjee (2014) Computational and Functional Characterization of Angiogenin Mutations, and Correlation with Amyotrophic Lateral Sclerosis, PloS one 9 (11), e111963.
  15. A Shukla, AK Padhi, J Gomes, M Banerjee (2014) The VP4 peptide of hepatitis A virus ruptures membranes through formation of discrete pores, Journal of virology 88 (21), 12409-12421.
  16. S Kamthan, J Gomes, PK Roychoudhury (2014) Production of monoclonal antibodies for breast cancer by HB8696 hybridoma cells using novel perfusion system, Enzyme and microbial technology 64, 44-51.
  17. S Kumar, N Srivastava, BS Gupta, RC Kuhad, J Gomes (2014) Lovastatin production by Aspergillus terreus using lignocellulose biomass in large scale packed bed reactor, Food and Bioproducts Processing 92 (4), 416-424.
  18. Suhas V. Vasaikar, B. Jayaram, James Gomes (2014) Rapid computation and interpretation of Boolean attractors in biological networks, Journal of Complex Networks, (2014) Page 1 of 11 doi:10.1093/comnet/CNU011.
  19. Padhi, A.K., Suhas V.V, B Jayaram , Gomes J, Fast prediction of deleterious angiogenin mutations causing amyotrophic lateral sclerosis. FEBS Lett. (2013), http://dx.doi.org/10.1016/j.febslet.2013.04.022
  20. Aditya K. Padhi, B. Jayaram, James Gomes (2013), Scientific Reports (NPG), SCIENTIFIC REPORTS,3:1225
  21. S V Vasaikar, A K Padhi, B Jayaram and J Gomes, NeuroDNet - an open source platform for constructing and analyzing neurodegenerative disease networks, (2013) BMC Neuroscience, BMC Neuroscience 2013, 14:3.
  22. A. Padhi, H. Kumar, S. V. Vasaikar, B. Jayaram and J. Gomes*, (2012) Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis, PLoS ONE 7(2), e32479.
  23. Bala K, Gomes J and Gohil NK (2011) Interaction of glycated human serum albumin with endothelial cells in a hemodynamic environment: Structural and functional correlates, Molecular BioSystems, 7(11): 3036-3041.

International Conferences

  1. S Kamthan, J Singh, K Banerjee, PK Roy Choudhury and J Gomes, Application of peripheral cornea from keratoplasty in cell culture, 3rd Annual International Conference on Advances in Biotechnology BIOTECH 2013, 18-19 March 2013, Singapore
  2. S V Vasaikar, SK Bhattacharya and J Gomes, A Computational Analysis of Multiple Sclerosis Using Protein-Protein Interaction Network, 3rd Annual International Conference on Advances in Biotechnology BIOTECH 2013, 18-19 March 2013, Singapore
  3. Backliwal G, Kumar S and Gomes J (2011) Comparison of Lovastatin Synthesis using Glucose and Lactose by Metabolic Flux Analysis, BioMicroWorld 2011, Malaga, Spain, 14-16 September, 6 pages.
  4. Subramanian K and Gomes J (2011) Identification of Metabolic States and their Relation to Operational Conditions in Urokinase Production by HT1080 Cells, Malaga, Spain, 14-16 September, 6 pages.
  5. Ranjan AP and Gomes J (2010) Decoupled Adaptive Control of Glucose and Dissolved Oxygen for Fed-batch Methionine Production Using Linear Reference Model, American Control Conference 2010, Baltimore, Maryland, USA June 30 - July 2, pp 5862-5867.

National Conferences

  1. Kumar S, Sharma A, Shrivastava N and Gomes J* (2008) Screening and Optimization of Carbon and Nitrogen Source for Increasing Lovastatin Production by Submerge Fermentation Using Aspergillus sp., Chemcon 2008, December 27-30, Chandigarh, 9 pages.

  2. Gomes J*, Trivedi P, Mittal A, Ghosh S and Sengupta B (2008) Metabolic Network Dynamics Using Genetic Circuits, Chemcon 2008, December 27-30, Chandigarh, 9 pages BPT 20..

Research Collaborations

Prof. Bhaskar Sengupta, Queens University, Belfast, UK

Prof. Sanjoy BhattacharyaUniversity of Miami, USA

Anurag S. Rathore, Department of Chemical Engineering, IIT Delhi