Indian Institute of Technology Delhi
New Delhi, India
Department of Biochemical Engineering and BiotechnologySundar Lab Home | Research | Tools and Databases | Publications | Lab Members | Collaborations | Projects | Photos | Career | Courses | Awards | Links | Publications Selected Publications
Year 2012
Roy, S., Dutta, S., Khanna, K., Singla, S. and Sundar, D. (2012). Prediction of DNA-binding specificity in zinc finger proteins. J. Biosciences (accepted)Grover, A., Priyandoko, D., Gao, R., Shandilya, A., Widodo, N., Bisaria, V.S., Kaul, S., Wadhwa, R. and Sundar, D. (2012). Withanone binds to mortalin and abrogates mortalin-p53 complex: computational and experimental evidence. International Journal of Biochemistry and Cell Biology 44(3): 496-504. [PubMed]
Grover, A., Singh, R., Shandilya, A., Priyandoko, D., Agrawal, V., Bisaria, V.S., Wadhwa, R., Kaul, S. and Sundar, D. (2012). Ashwagandha-derived withanone targets TPX2-Aurora A complex: computational and experimental evidence to its anticancer activity. PLoS ONE 7(1): e30890 [PubMed]
Grover, A., Katiyar, S., Jeyakanthan, J., Dubey, V.K. and Sundar, D. (2012). Mechanistic insights into the dual inhibition strategy for checking Leishmaniasis. J. Biomolecular Structure and Dynamics (in press)
Grover, A., Katiyar, S., Singh, S.K., Dubey, V.K. and Sundar, D. (2012) A Leishmaniasis study: structure-based screening and molecular dynamics mechanistic analysis for discovering potent inhibitors of spermidine synthase.Biochimica et Biophysica Acta - BBA: Proteins and Proteomics (accepted)
Grover, A., Shakyawar, S.K., Saudagar, P., Dubey, V.K. and Sundar, D. (2012). Epitopic analysis of potential vaccine candidate in Leishmania infantum for development of human vaccine. Letters in Drug Design & Discovery (accepted)
Sarkar, A., Kumar, S., Grover, A. and Sundar, D. (2012) Protein aggregation in neurodegenerative diseases: Insights from computational analyses. Current Bioinformatics 7(1): 87-95 [crossref]
Grover, A., Shandilya, A., Agrawal, V., Bisaria, V.S. and Sundar, D. (2012). Computational evidence to inhibition of human acetyl cholinesterase by withanolide A for Alzheimer treatment. J. Biomolecular Structure and Dynamics 29(4): 651-662. [PubMed]
Grover, A., Yadav, J.S.S., Biswas, R., Pavan, C.S.S., Mishra, P., Bisaria, V.S. and Sundar, D. (2012). Production of monoterpenoids and aroma compounds from cell suspension cultures of Camellia sinensis. Plant Cell, Tissue and Organ Culture 108(2): 323-331 [crossref]
Grover, A., Shandilya, A, Agrawal, V., , Bisaria, V.S. and Sundar, D. (2012). Computational insights into the binding mechanisms of withafern A, a herbal anticancer drug. In: Bioinformatics: Genome Bioinformatics and Computational Biology , Tuteja, R. (Ed.), Nova Science Publishers Inc., Hauppahauge, NY, USA (ISBN: 978-1-62100-913-9) (in press) [crossref]
Year 2011
Our work has been highlighted in Nature India (doi:10.1038/nindia.2011.9) [crossref] [PDF]Grover, A., Agrawal, V., Shandilya, A., Bisaria, V.S. and Sundar, D. (2011). Non-nucleosidic inhibition of Herpes simplex virus DNA polymerase: Mechanistic insights into the anti-herpetic mode of action of herbal drug withaferin-A. BMC Bioinformatics 12(11): S22. [PubMed]
Grover, A., Shandilya, A., Agrawal, V., Pratik, P., Bhasme, D., Bisaria, V.S. and Sundar, D. (2011) Blocking the chaperone kinome pathway: mechanistic insights into a novel dual inhibition approach for supra-additive suppression of malignant tumours. Biochem. Biophys. Res. Commun. 404(1): 498-503. [PubMed]
Grover, A., Shandilya, A., Agrawal, V., Pratik, P., Bhasme, D., Bisaria, V.S. and Sundar, D. (2011) Hsp90/Cdc37 chaperone/co-chaperone complex, a novel junction anticancer target elucidated by the mode of action of herbal drug withaferin-A. BMC Bioinformatics 12(1): S30. [PubMed]
Sarkar, A., Kumar, S. and Sundar, D. (2011) The G-Protein coupled receptors in the putterfish Fugu rubripes. BMC Bioinformatics 12(1): S3. [PubMed]
Punetha, A., Shanmugam, K. and Sundar, D. (2011) Insight into the enzyme-inhibitor interactions of the first experimentally determined human aromatase. J. Biomolecular Structure and Dynamics 28(5): 759-771. [PubMed]
Year 2010
Grover, A., Pandey, A., Choudhary, K., Gupta, K. and Sundar, D. (2010) Re-programming DNA-binding specificity in zinc finger proteins for targeting unique address in a genome. Systems and Synthetic Biology 4(4): 323-329. [PubMed]Grover, A., Shandilya, A., Punetha, A., Bisaria, V.S. and Sundar, D. (2010) Probing the anticancer mechanism of prospective herbal drug withaferin-A on mammals: a case study on human and bovine proteasomes. BMC Genomics 11(4):S15. [PubMed]
Grover, A., Shandilya, A., Bisaria, V.S. and Sundar, D. (2010) Inhibition of the NEMO/IKKß association complex formation, a novel mechanism associated with the NF-kB activation suppression by Withania somnifera’s key metabolite withaferin-A. BMC Genomics 11(4):S25. [PubMed]Molparia, B., Goyal, K., Sarkar, A., Kumar, S. and Sundar, D. (2010) . Zif-Predict: a web tool for predicting DNA-binding specificity in C2H2 zinc finger proteins. Genomics, Proteomics & Bioinformatics 8(2): 122-126. [PubMed] [Zif-Predict]
Sarkar, A., Kumar, S., Grover, A., Punetha, A. and Sundar, D. (2010) Analysis and prediction of DNA-recognition by zinc finger proteins: applications in genome modification. In:Biomedical Engineering and Information Systems: Technologies, Tools and applications, Shukla, A. and Tiwari, R. (Eds.) , pp. 303-317, IGI Global, Hershey, PA, USA. (ISBN: 978-1-61691-004-3) [crossref]
Year 2009
Jayakanthan, M., Muthukumaran, J., Chandrasekar, S., Chawla, K., Punetha, A. and Sundar, D. (2009). ZifBASE: a database of zinc finger proteins and associated resources. BMC Genomics 10: 421. [PubMed] [ZifBASE]
Kumar, S., Sarkar, A. and Sundar, D. (2009). Controlling aggregation propensity in A53T mutant of alpha-synuclein causing Parkinson's disease. Biochem. Biophys. Res. Commun. 387(2): 305-309. [PubMed]
Jayakanthan, M., Wadhwa, G., Madhan Mohan, T., Arul, L., Balasubramanian, P. and Sundar, D. (2009). Computer Aided Drug Design for cancer-causing H-Ras P21 Mutant Protein. Letters in Drug Design & Discovery 6(1): 14-20. [crossref]
Balachandran, N., Kichenamourthy, S., Muthukumaran, J., Jayakanthan, M., Chandrasekar, S., Punetha, A. and Sundar, D. (2009). Diversity of true mangroves and their associates in the Pondicherry region of South India and development of a mangrove knowledgebase. J. Ecol Nat. Environ. 1(5): 99-105 . [Mangroves-dB]
Kumar, S., Sarkar, A. and Sundar, D. (2009). Aggregation studeis on mutants of alpha-synuclein leading to Parkinson's disease. Biobytes 4: 58-59. [crossref]
Year 2008
Gowthaman, U., Jayakanthan, M. and Sundar, D. (2008) Molecular docking studies of dithionitrobenzoic acid and its related compounds to protein disulphide isomerase: computational screening of inhibitors to prevent HIV-1 entry. BMC Bioinformatics 9 (12):S14. [PubMed]
Sundar, D. and A.R. Reddy (2008). Detection of a rapidly accumulating 50 kDa polypeptide and increased rubber accumulation in guayule under low temperatures. Scient. Res. Essays 3(8): 338-342.
< Year 2008
Palaniraja, T., Damodaran, B.G.V., Deepa, M., Prathibha, S. and Sundar, D. (2007). Enzif: a tool for targeted genome engineering. Biobytes 2: 22-24. [crossref]
Sundar Durai, Bosley, A., Bridgeman, A., Chandrasegaran, S. and Ostermeier, M. (2006) A bacterial one-hybrid selection system for interrogating zinc finger-DNA interactions. Combinatorial Chemistry & High Throughput Screening 9(4): 301-311. [PubMed]
Sundar Durai, Kandavelou, K., Mani, M., Joy, W., Porteus, M.H. and Chandrasegaran, S (2005) Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Research 33(18): 5978-5990. [PubMed]
Kandavelou, K., Mani, M., Sundar Durai and Chandrasegaran, S (2005) "Magic" scissors for genome surgery. Nature Biotech. 23(6): 686-687. [PubMed]
Mani, M., Kandavelou, K., Dy, F.J., Sundar Durai and Chandrasegaran, S (2005) Design, engineering and characterization of zinc finger nucleases for gene targeting. Biochem. Biophys. Res. Commun. 335: 447-457. [PubMed]
Kandavelou, K., Mani, M., Sundar Durai and Chandrasegaran, S. (2004) Engineering and applications of chimeric nucleases. Nucleic Acids and Molecular Biology. Vol.14. In: Pingoud, A.M. (Ed.) Restriction Endonucleases, pp. 413-434, Springer-Verlag, Berlin, Germany [crossref]
Sundar Durai, Bosley, A., Bridgeman, A., Chandrasegaran, S. and Ostermeier, M. (2004) A bacterial one-hybrid selection system for interrogating zinc finger-DNA interactions. FASEB Journal , 18(8): C174.
Reddy, A.R., Sundar, D. and Gnanam, A. (2003) Photosynthetic flexibility in Pedilanthus tithymaloides Poit, a CAM plant. J. Plant Physiol. 160(1): 75-80. [PubMed]
Sundar, D. and Reddy, A.R. (2001) Interactive influence of temperature and growth light intensity on rubber accumulation and rubber transferase activity in guayule (Parthenium argentatum Gray). J. Plant Physiol. 158(10): 1291-1297.
Sundar, D. and Reddy, A.R.(2000) Characterization of rubber latex particles and the associated proteins from Ficus elastica Roxb. J. Plant Biol. 27(2): 139-144.
Magazine coverage of our research
India's popular only Science & Environment fortnightly (Down To Earth) published by Indian Society for Environmental Communications, highlighted our work on rubber biosynthesis. Down to Earth (March 15, 2006 ) pp. 31. [PDF]
