james gomes

Projects

1. Modulators of a-4-containing GABAA receptors: potential therapy for focal cortical dysplasia (FCD), CoPI

2. Calcium-permeable ion channels as therapeutic targets to manage neuropathic pain, CoPI

3. Developing Predictive Models for drug likeness of small molecules, CoPI

4. Establishment of a Centre of Excellence in Bioinformatics and Computational Biology at IIT Delhi, with the theme as Development of Genome to Hit (Dhanvantari) pipeline: Genome ? Gene ? Protein ? Drug (Centre of Excellence Main project), CoPI

 

Peer Reviewed Journals

  1. Joshi, S., Gomes, J. (2026). Affordability and Financial Challenges in the Internationalization of Higher Education in India. In: Misra, P.K., Moitra, N. (eds) India's Higher Education in the Global Context. Springer, Singapore. https://doi.org/10.1007/978-981-95-2367-2_13
  2. Vicky Kachera, Dimple Patel, Saurabh Mishra, Alka Mishra, James Gomes, Rahul Garg , The Effects of Yoga Nidra Practice on EEG Oscillations: A Systematic Review.   doi: https://doi.org/10.1101/2025.06.16.25329676
  3. N Singh, D Mishra, J Gomes. Deleterious Sequestosome 1 mutations G262R and P438L in amyotrophic lateral sclerosis cause autophagy and oxidative stress imbalance, Neuroscience (2025) 581, 233-246. https://doi.org/10.1016/j.neuroscience.2025.07.011 
  4. U Dave, P Narain, D Mishra, J Gomes. Aggregation of E121K mutant D-amino acid oxidase and ubiquitination-mediated autophagy mechanisms leading to amyotrophic lateral sclerosis, J. Neurological Sci (2024) 456, 122845.
  5. S Khan, S Upadhyay, U Dave, A Kumar, J Gomes. Structural and mechanistic insights into ALS patient derived mutations in D-amino acid oxidase, Int J Biol Macromol (2024) 256, 128403.
  6. D Mishra, P Narain, U Dave, J Gomes. Role of ALS-associated OPTN-K489E mutation in neuronal cell-death regulation, Mol Cellular Neurosci (2023) 127, 103904.
  7. U Dave, S Khan, J Gomes. Characterization of E121K mutation of D-amino acid oxidase–insights into mechanisms leading to amyotrophic lateral sclerosis, Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics (2023) 1871 (6), 140947.
  8. S Nikita, S Mishra, K Gupta, V Runkana, J Gomes, AS Rathore. Advances in bioreactor control for production of biotherapeutic products, Biotechnol Bioeng (2023) 120 (5), 1189-1214.
  9. S Khan, J Gomes. Structure-function insights into the role of D-amino acid oxidase mutations implicated in amyotrophic lateral sclerosis. Biophysical Journal (2023)122 (3), 419a.
  10. S Shekhar, S Dhir, J Gomes, B Jayaram. Academic bioinformatics activities joining hands with entrepreneurial ventures: a way to go in life science research (case studies from Indian academia, start-ups and the life-science sector), Int J Res Innov Commercial (2023) 5 (1) 70–105.
  11. B Kundu, A Mishra, P Gupta, AK Pandey, P Pradhan, MB Menon, J Gomes, V Perumal, S Dhamija. Primer sets, biomarkers, kit and applications thereof. US Patent App. 17/422, 575 (2022).
  12. AK Padhi, R Shukla, P Narain, J Gomes. A distant angiogenin variant causes amyotrophic lateral sclerosis through loss-of-function mechanisms: Insights from long-timescale atomistic simulations and conformational dynamics, Comp Biol Med (2021) 135, 104602.
  13. S Khan, J Gomes. Neuropathogenesis of SARS-CoV-2 infection (2020) Elife 9, e59136.
  14. A Mishra, AK Pandey, P Gupta, P Pradhan, S Dhamija, J Gomes, B Kundu, Mutation landscape of SARS-CoV-2 reveals five mutually exclusive clusters of leading and trailing single nucleotide substitution  (2020) bioRxiv, 2020.05. 07.082768.
  15. P Pradhan, AK Pandey, A Mishra, P Gupta, PK Tripathi, MB Menon, J Gomes, V Perumal, B Kundu (2020) Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag, bioRxiv.
  16. M Kumar, A Pant, R Bansal, A Pandey, J Gomes, K Khare, AS Rathore, M Banerjee. Electron microscopy-based semi-automated characterization of aggregation in monoclonal antibody products, Comp Struct Biotechnol J (2020) 18, 1458-1465.

    17. EARLIER PAPERS

    1. SV Vasaikar, B Jayaram, J Gomes (2015) Rapid computation and interpretation of Boolean attractors in biological networks, Journal of Complex Networks 3 (1), 147-157.
    2. SV Vasaikar, S Ghosh, P Narain, A Basu, J Gomes (2015) HSP70 mediates survival in apoptotic cells—Boolean network prediction and experimental validation, Frontiers in cellular neuroscience, 9: 319. doi:10.1093/comnet/CNU011.
    3. AK Padhi, K Banerjee, J Gomes, M Banerjee (2014) Computational and Functional Characterization of Angiogenin Mutations, and Correlation with Amyotrophic Lateral Sclerosis, PloS one 9 (11), e111963.
    4. S Kumar, N Srivastava, BS Gupta, RC Kuhad, J Gomes (2014) Lovastatin production by Aspergillus terreus using lignocellulose biomass in large scale packed bed reactor, Food and Bioproducts Processing 92 (4), 416-424.
    5. Suhas V. Vasaikar, B. Jayaram, James Gomes (2014) Rapid computation and interpretation of Boolean attractors in biological networks, Journal of Complex Networks, (2014) Page 1 of 11 doi:10.1093/comnet/CNU011.
    6. Padhi, A.K., Suhas V.V, B Jayaram , Gomes J, Fast prediction of deleterious angiogenin mutations causing amyotrophic lateral sclerosis. FEBS Lett. (2013), http://dx.doi.org/10.1016/j.febslet.2013.04.022
    7. Aditya K. Padhi, B. Jayaram, James Gomes (2013), Scientific Reports (NPG), SCIENTIFIC REPORTS,3:1225
    8. S V Vasaikar, A K Padhi, B Jayaram and J Gomes, NeuroDNet - an open source platform for constructing and analyzing neurodegenerative disease networks, (2013) BMC Neuroscience, BMC Neuroscience 2013, 14:3.
    9. A. Padhi, H. Kumar, S. V. Vasaikar, B. Jayaram and J. Gomes*, (2012) Mechanisms of Loss of Functions of Human Angiogenin Variants Implicated in Amyotrophic Lateral Sclerosis, PLoS ONE 7(2), e32479.

    International Conferences

    1. Nidhi Singh, James Gomes. “Pathophysiology pathways of SQSTM1 variants in Amyotrophic Lateral Sclerosis”, Oral presentation at 4th International Conference on Neuroscience and Neurology organized by PULSUS and the Editors of Journal of Psychology & Psychotherapy at Dubai, UAE from April 18th – April 19th, 2024.
    2. Nidhi Singh, James Gomes “Elucidation of the role of SQSTM1 variants in Amyotrophic Lateral Sclerosis”, Poster presentation at International Conference organized by Gordon Research Conferences on Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases at Les Diablerets, Switzerland from July 2nd – July 7th, 2023.
    3. Dibyakanti Mishra, James Gomes, poster at the 67th Biophysical Society Annual Meeting (BPS-2023) held in San Diego, California, USA.
    4. Dibyakanti Mishra, James Gomes, Gordon Research Conference on Amyotrophic Lateral Sclerosis (ALS) and Related Motor Neuron Diseases, July 21 - 26, 2019 at West Dover, VT, US.
    5. Upma Dave, James Gomes, Gordon Research Conference on Amyotrophic Lateral Sclerosis (ALS) and Related Motor Neuron Diseases, July 21 - 26, 2019 at West Dover, VT, US.
    6. Budhaditya Chatterjee, Soumen Basak, James Gomes. Immune differentiation regulator p100 tunes NF-?B responses to TNF Systems Immunology Meeting 2019, Cold Spring Harbor Laboratory, NY, USA.
    7. Budhaditya Chatterjee, Soumen Basak, James Gomes. Late phase synthesis of I?Ba insulates TLR4 induced canonical NF?B pathway from non-canonical signalling in macrophages, Systems Biology of Human Diseases 2018, (Selected for travel award) UCLA, CA, USA.
    8. Priyam Narain, Ashutosh Pandey, Shruti Gupta, Rohit Bhatia, Vivekanandan Perumal, James Gomes “Targeted next-generation sequencing of ALS-related genes in Indian ALS patients” (2017) Theme 1 Genetics and genomics, Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18:sup2, 78-101, DOI: 10.1080/21678421.2017.1371515. 28th International Symposium on ALS/ MND, Boston, USA (8th -10th Dec 2017).
    9. Priyam Narain, Vivekanandan Perumal, Inder Singh, Rohit Bhatia, James Gomes. “Infrequent occurrence of hexanucleotide repeat expansion in the C9orf72 gene among Indian ALS patients” (14/06/2015 to 17/06/2015) at EMBO-EMBL Mechanism of Neurodegeneration Heidelberg, Germany.

    National Conferences

    1. Priyam Narain, James Gomes, Rohit Bhatia, and Perumal Vivekanandan “ATXN2 Intermediate Length Repeat Expansions in Indian Patients with Amyotrophic Lateral Sclerosis” (29/10/2017 to 31/10/2017) at XXX Annual Meet of Indian Academy of Neurosciences and International Conference on Translational Neurosciences and its Application in Protection of Mental Health at Ravenshaw University, Cuttack, Orissa, India.

    2. Dibyakanti Mishra, James Gomes "International Conference of Neuroscience on Translational Research in improving mental health" at Banaras Hindu University, Banaras, India, held on October 29-31, 2018.

    Research Collaborations

    Prof. Bhaskar Sengupta, Heriot Watt University, Edinburg, UK

    Prof. Sanjoy BhattacharyaUniversity of Miami, USA

    Anurag S. Rathore, Department of Chemical Engineering, IIT Delhi