Biosketch
Dr. Shashank Deep (PhD, FRSC, FRSB)
Dr. Shashank Deep is a professor in Department of Chemistry, Indian Institute of Technology Delhi. Dr. Deep obtained his Ph.D. degree from Indian Institute of Technology Delhi. He then moved to Prof. Hinck laboratory at Department of Biochemistry, University of Texas health science center at San Antonio, Texas, USA on a post-doctoral assignment. His second postdoctoral work was with Prof. Erik Zuiderweg at Department of Biophysics, University of Michigan, Ann Arbor, MI, USA where he used NMR to study the protein-protein interaction, protein dynamics and protein structure. He joined the department as an assistant professor in 2005. He became Associate Professor in 2011 and Professor in 2018. Dr. Deep is a fellow of Royal Society of Chemistry, London and Fellow of Royal Society of Biology, London. Dr. Deep is a member of American Chemical society, Protein Society, Indian Biophysical society. He is joint secretary of Protein Society (India). Dr. Deep has a vibrant laboratory with good facilities for protein expression and purification, kinetic/thermodynamic/morphological characterization of proteins and their aggregates, structural characterization of proteins and their complexes with receptors/ligands/drugs, energetic/ thermodynamic characterization of protein stability/ protein complex formation. Dr. Deep laboratory is interested in understanding the reasons responsible for various diseases and formulate strategies to counter them. Fibril formation is associated with several neurodegenerative diseases. The disruption in receptor ligand interaction is another major cause of several diseases. Keeping this in mind, his group focuses on (i) developing inhibitors for fibril formation (ii) modulating interaction of receptor with ligands with drug like candidate (iii) looking of new targets for tuberculosis and (iv) methodology development for rigorous analysis of experimental data (v) developing strategies to increase the refolding yield of various cysteine rich proteins. A variety of experimental techniques fluorescence, ITC, DLS, CD and NMR and computer simulation are being used to carry out these studies.