Design Optimal ZFPs for Target DNA Sequences

Click the "Tutorials" button to see how to use ZifNN!
Click the "Run" button to start using the tool!

Neural Networks Based Predictions

Click the "Tutorials" button to see how to use ZifNN!
Click the "Run" button to start using the tool!

Developed and maintained by
Shayoni Dutta, Spandan Madan, Harsh Parikh & D. Sundar
IIT Delhi, INDIA

Tutorials Run Tool

3 simple steps to the optimal ZFP

Upload Sequence

Enter your 9bp sequence in the box

Click Submit

Click Submit to run, or
the ABOUT to read more about the tool.

Sit back, Relax.

Let us do what we do best! As easy as 1,2,3!
You will automatically be redirected to the results page once ZifNN is done working!



Run ZifNN

Simply enter a 9bp DNA sequence (Case Sensitive)


*[Please be patient, may take upto 10-15 sec depending upon your internet speed]




A better look at how the tool works

Synergistic Binding

  • Synergistic mode of binding comes closest to mimicing natural binding of ZFPs to DNA
  • it takes into account both cross-strand interactions and co-operativity of the fingers.

Neural Network Predictor

  • ZifNN uses an ensemble machine learning technique
  • It utilizes 100 micro neural network models to predict the most suitable ZFP

Team Members

Shayoni Dutta

PhD, IIT Delhi

Currently Working at the molecular modeling lab at IIT Delhi.
Interested in algorithmic approaches to study Protein-DNA interations.
Has been involved extensively in projects on molecular modeling and dynamic simulations.

Spandan Madan

Btech & Mtech, IIT Delhi

Currently Working on a collaborative masters project between IIT delhi and the University of Pennsylvania as his thesis.
He is Interested in using Mathematics and Computer Science to solve problems in biology.

Harsh Parikh

Researcher at IBM, India

Harsh is a math enthusiast who completed his bachelors in computer science from IIT Delhi recently in 2015
He is currently working as at IBM at the interface of Computer Science and Biology. In his free time, he loves writing and blogging!

Dr.D.Sundar

Associate Professor, IIT Delhi

DuPont Young Professor at IIT Delhi and the advisor of the molecular modelling research group. Current research includes - 1)Design of ZFPs for genome editing and 2) Studying biological acitivity of natural drugs , with a long term goal of studying DNA binding specificities.

Contact Details

We Are Social!

Feel free to contact us for any feedback, or suggest improvements. We would love to hear from you!

Contact us at:

Email : sundar@dbeb.iitd.ac.in

Call : +91-11-26596316

Web-Page : D. Sundar Lab, IIT Delhi

Address :

Molecular Modelling Laboratory
Department of Biochemical Engineering and Biotechnology
Indian Institute of Technology (IIT) Delhi
Hauz Khas
New Delhi - 110016
INDIA