Allosteric modulators (PAMs and NAMs) of ligand-gated ion channels, including nAChRs, polymodal ion channels, such as TRPML3 and TPC2, and GPCRs have been touted as effective therapeutic candidates in neurodegenerative, neuropsychiatric disorders and neuropathic pain. Our lab is strongly committed to identify novel candidate drug molecules against the above ion channel targets. We have helped set up a fluorescence-based high-throughput drug screening (HTS) platform (FLIPR Penta) on IITD campus, the first of its kind in the country, to expedite drug screening. Our current work in this area is focused on establishing a robust pipeline consisting of in silico high-throughput compound screening, structural dynamics study, experimental HTS screening and functional validation of the candidate drugs.