Dr. Sheetal Bandhu
DST Women Scientist (Research Interest: Recombinant therapeutic protein preparation and characterization): August 2023 continuing
M.Sc. Biotech:2007
H. N. B. Garhwal University, Uttarakhand.
Ph.D Science:2018
CSIR-Indian Institute of Petroleum, Dehradun.
Institute PDF (2019-2022)
Indian Institute of Technology Delhi
E-mail:
sbandhu@bioschool.iitd.ac.in
Reading, Travelling.Hobbies & Interests::
Research Interest:
Current Area of work:
Expression of therapeutically important proteins in a heterogeneous host (bacteria, yeast, plant, insect or mammalian cell lines etc.) are low cost alternative methods of their production as opposed to their extraction from natural sources such as blood etc. Among the expression hosts, E Coli seems to be most promising host owing to its high growth rate (doubling time of E. coli is 20 minutes), low media costs, amenability for genetic modification, easier scalability. Our group is actively involved in the preparation and characterisation of recombinant therapeutic proteins and proteins of commercial interests in Escherichia coli system. We are trying to develop chaperone assisted method to enhance the production of functional recombinant proteins for therapeutic and commercial purposes.
Publications:
1 Bandhu S, Srivastava A, Ghosh D, Chaudhuri TK. Yeast Single Cell Oils from Bioresources: Current Developments in Production and Applications. Current Sustainable/Renewable Energy Reports. 2020 Oct 7:1-2.
2 Srivastava A, Bandhu S. Technological Challenges in Enzymatically Produced Functional Foods. Current Sustainable/Renewable Energy Reports. 2020 Apr 22:1-9.
3 Bandhu S, Bansal N, Dasgupta D, et al., (2019). Overproduction of single cell oil from xylose rich sugarcane bagasse hydrolysate by an engineered oleaginous yeast Rhodotorula mucilaginosa IIPL32. Fuel 254 115653; IF: 6.609
4 S Bandhu, MB Khot, T Sharma, et al., (2018). Single Cell Oil from Oleaginous Yeast Grown on Sugarcane Bagasse-Derived Xylose: An Approach toward Novel Biolubricant for Low Friction and Wear. ACS Sustainable Chem. Eng., 6 (1), 275–283.; IF:8.198
5 Dasgupta D, Ghosh D, Bandhu S, Adhikari DK. Lignocellulosic sugar management for xylitol and ethanol fermentation with multiple cell recycling by Kluyveromyces marxianus IIPE453. Microbiological research. 2017 Jul 1;200:64-72; IF: 5.415
6 Dasgupta D, Sharma T, Bhatt A, Bandhu S, Ghosh D (2017). Cultivation of oleaginous yeast Rhodotorula mucilaginosa IIPL32 in split column airlift reactor and its influence on fuel properties. Biocatal Agric Biotechnol 10, 308-316. IF: 2.513
7 Dasgupta D, Bandhu S, Adhikari DK, Ghosh D (2017). Challenges and prospects of xylitol production with whole cell bio-catalysis: a review. Microbiol Res 197, 9-21. IF: 5.415
8 Bandhu S, Sharma T, Agrawal D, Ghosh D, Adhikari DK, Dasgupta D. Influence of cytosolic malic enzyme in oleaginous yeast Rhodotorula mucilaginosa IIPL32 for lipid biosynthesis. J. Bioanal. Biomed. 2017;9:100-6.
9 Dasgupta D, Ghosh D, Bandhu S, Agrawal D, Suman SK, Adhikari DK (2016). Purification, characterization and molecular docking study of NADPH dependent xylose reductase from thermotolerant Kluyveromyces sp. IIPE453. Proc Biochem 51, 124-133.IF: 3.757
10 Ravitchandirane, G., Bandhu, S. & Chaudhuri, T.K. Multimodal approaches for the improvement of the cellular folding of a recombinant iron regulatory protein in E. coli. Microb Cell Fact 21, 20 (2022). IF: 6.3
11 Srivastava A, Bandhu S. Biotechnological advancements and challenges in textile effluents management for a sustainable bioeconomy: Indian case studies. Case Studies in Chemical and Environmental Engineering. 2022 Feb 1:100186.