Shubham Vashishtha
PhD Research Scholar
Kusuma School of Biological Sciences
Indian Institute of Technology, Delhi
Email: vashishtha.sv05@gmail.com, blz178575@iitd.ac.in
Education: B.Tech-M.Tech Dual degree, Jaypee University of information technology Wakhnaghat Solan
Thesis Research:
Identification and exploration of potential drug targets againts Neisseria gonorrhoeae
Neisseria gonorrhoeae is generally regarded as a human commensal pathogen. Although, there are two strains N. gonorrhoea and N. meningitidis which cause disease in humans. N gonorrhoea cause sexually transmitted disease (STD) whereas, N. meningitidis causes septicaemia and meningitis. Ng is known to show broad-spectrum antibiotic resistance, which makes it very difficult to treat. Present day treatments for gonorrhoea infections include combinatorial treatment with ceftriaxone and azithromycin, which in most cases are sufficient to tackle this infection. Quite alarmingly, of late, there are cases of antibiotic resistance strains emerging from all around the world, including Europe, USA, India and Malasia. So, my work focus on exploring different proteins which can be used as potential drug targets againts Neisseria gonorrhoeae.
Publications:
* Vashishtha, S., Singh, J., & Kundu, B*. (2022). Antimicrobial‐resistant Neisseria
gonorrhoeae can be targeted using inhibitors against evolutionary conserved
L‐asparaginase. Journal of Cellular Biochemistry, 123(7), 1171–1182.
* Vashishtha, S., Thakur, S., Singh, J., Adhana, S., & Kundu, B. (2023). Evolutionarily
conserved heat shock protein, HtpX, as an adjunct target against antibiotic-resistant
Neisseria gonorrhoeae. Journal of cellular biochemistry, 10.1002/jcb.30461.
* Singh, J., Vashishtha, S., Rahman, S. A., Ehtesham, N. Z., Alam, A., Kundu, B., &
Dobrindt, U. (2022). Energetics of Spike Protein Opening of SARS-CoV-1 and SARS-
CoV-2 and Its Variants of Concern: Implications in Host Receptor Scanning and
Transmission. ACS Biochemistry, 61(20), 2188-2197.
* Saha, S., Vashishtha, S., Kundu, B., & Ghosh, M. (2022). In-silico design of an
immunoinformatics based multi-epitope vaccine against Leishmania donovani. BMC
Bioinformatics, 23(1), 1-28.
* Singh, J., Quadir, N., Vashishtha, S., Chakraborty, A., Alam, A., Kundu, B., ... &
Hasnain, S. E. (2023). Polypharmacological repurposing approach identifies approved
drugs as potential inhibitors of Mycobacterium tuberculosis. Biochemical Journal,
BCJ20230143.
* Singh J , Vashishtha S , Kundu B*, " Spike protein mutations induced changes in kinetic
and thermodynamic behaviour of its receptor binding domains explains their higher
propensity to attain open states in SARS-CoV-2 variants of concern "ACS Central
Science. (# Equal first author) (under revision)
* Banik, A., Chaudhuri, R. D., Vashishtha, S., Gupta, S., Kar, A., Bandyopadhyay, A., . . .
Sarkar, S. (2023). Deoxyelephantopin—a novel PPARγ agonist regresses pressure
overload-induced cardiac fibrosis via IL-6/STAT-3 pathway in crosstalk with PKCδ.
European Journal of Pharmacology, 175841
* Gupta, A., Singh, P., Mehrotra, A., Gautam, A., Srividya, K., Vashishtha, S...,
Upadhayay, K. (2022). Penetratin inhibits α-synuclein fibrillation and improves
locomotor functions in mice model of Parkinson's disease. bioRxiv, 2022.2006.
2024.497475
* Vashishtha, S., Barwal, T. S., & Bansal, S. (2019). Structure and Sequence-Based
Analysis of Pullulanases: Understanding Dual Catalytic Mechanism. Protein and
Peptide Letters, 26(12), 893-903.
Awards/Fellowships/Grants:
Junior Research Fellowship (JRF) awarded by Indian Institute of technology Delhi.
Qualified CSIR-NET(JRF) December, 2017. AIR 29
Qualified Uttrakhand State entrance test (USET), 2017.
Qualified GATE 2016
Poster/Workshop/Conference
Attended conference titled " Conceptual advances in Biophysics and its application" in 44th Indian Biophysical Society meeting, held at ACTREC, Navi Mumbai from 30th March to 1st April 2022.
Presented abstract titled "Investigating the role of l-asparaginase as a potential therapeutic target against gonorrhea infections." in Biophysical society 2022 BPS Annual meeting, on 19-23 Feb 2022, San Francisco, California USA.
Conducted the workshop titled "Biomolecular spectroscopy and informatics" under the DST project in Bhaskaracharya college of applied sciences and delivered a hands-on training in "Computer aided drug design using structural based Drug design approach".
Attended "International conference on Drug Discovery" held at BITS Pilani Hyderabad campus, organised by Schrodinger from 27th Feb - 2nd March
Attended a three day workshop on “Drug Discovery” held at SCIS, JNU From 2-4 August 2018.
Attended a workshop on “Patent filing and Geographical Indications” held at Jaypee University on at 27th Feb 2017.
Attended a workshop on “Innovation and Intellectual Property Rights” held at Jaypee University on at 9th Dec 2016.
Previous Research Experience:
B.Tech. Thesis: "Structural analysis of various starch debranching enzymes and their production in Bacillus sp." Under the supervision of Dr.Saurab Bansal, at Jaypee University of information Technology, Wakhnaghat, Solan (2013-14).
M.Tech. summer project: "Homology modelling and comparative structural analysis of starch debranching enzymes of bacterial origin" Under the supervision of Dr.Saurab Bansal, at Jaypee University of information Technology, Wakhnaghat, Solan May-July 2016.
M.Tech. Thesis: "Screening and production of lignocellulosic enzymes from thermophilic bacterial isolates of the anaerobic system" Under the supervision of Dr.Saurab Bansal, at Jaypee University of information Technology, Wakhnaghat, Solan (2016-17).
