Addy_Research

Life and science have humbled me enough to realize that there will always be "something or someone" better. Thus, in my opinion, "excellence" is a kinetic manifestation of transient lifetimes in a non-stagnant/dynamic environment rather than a thermodynamic concept -

"Excellence (at any given point of time) is doing something for the first time or, doing something (being attempted/done by many others) better than all the others till that point of time"

Research "Mantra": Application of engineering principles towards mechanistic insights into biological systems and engineering robust solutions inspired by bio-design (self assembly and coordinated events).

Methodology and Tools: I develop rigorous quantitative analytical approaches for interpreting the results from both computational and wet experiments. The primary goal is not only to extract mechanistic information out of data, but also to be able to predict biological features in spite of "complexity" of the systems.

The real challenge in my scientific world lies in development and/or discovery of functional assays (both theoretical and experimental) for biological questions of my interest, data from which is then analyzed using self-developed robust analytical systems or theoretical (mechanistic) frameworks. Therefore, the computational component in my research is often more labor intensive than the experimental component.

The "Eureka" Drive: While today's definition of "successful" biological research falls under the category of "hypothesis driven science", I still prefer to enjoy the non-materialistic rewards in the world of "observation driven science". A substantial effort in my work goes into extracting quantitative signatures from biological data for (a) understanding origins of life, and, (b) developing functional applications, of the discovered signatures, relevant to biological research.

On the origins of life and roles of water as a chemical reactant + solvent in biological systems

in Evolutionary Biology—A Transdisciplinary Approach (2020) Springer International Publishing, Springer Nature Switzerland AG, Editor: P. Pontarotti, pp 169-201; J. Membr. Biol. (2022); Org. Biomol. Chem. (2023)

Biological Assembly: Proteins

J. Biomol. Struct. Dyn. (2021a, 2021b, 2020, 2019, 2018, 2013, 2012, 2011a, 2011b, 2010); BBA - Proteins Proteom. (2014, 2013); J. Biosci. (2012); Nature Precedings (2011)

Biological Assembly: Membranes

Scientific Reports (2019); J. Biomol. Struct. Dyn. (2018); Scientific Reports (2016); Mol. Biol.Cell (2015); J. Membrane Biol. (2013); J. Nanosci. Nanotechnol. (2010)

Biological Assembly: Bacterial Nano-magnets

Biotechnol. Bioeng. (2012); J. Biomed. Nanotechnol. (2011, 2008, 2007); Encyclopedia Nanosci. Nanotechnol. (2011); J. Nanosci. Nanotechnol. (2010); IEEE T. Magn.(2009); Nature India (2008)

Dynamics of biological systems: Analytical imaging of dynamic events in biological systems

J. Nanosci. Nanotechnol. (2009); Biotechnol. Bioeng. (2008); Mol. Biol. Cell (2007); J. Biomed. Nanotechnol. (2007); J. Cell Biol. (2005); J. Biol. Chem. (2004) ; Anal. Biochem. (2002) ; Biophys. J. (2001, 2002, 2003)

Dynamics of biological systems: Functional assay for bacterial motility using video microscopy with a 33 ms time resolution

Encyclopedia Nanosci. Nanotechnol. (2011); J. Biomed. Nanotechnol. (2008); Biotechnol. Bioeng. (2007); J. Biomed. Nanotechnol. (2007); J. Nanosci. Nanotechnol. (2006)

(Last updated March 31, 2023)