Research

Our current research initiatives are focused on:

  1. Development of engineered tissue constructs (e.g., cartilage and bone-like tissues) to replace diseased or injured organs,

  2. Establishment of simple in vitro disease model system (especially for arthritis, degenerative Intervertebral disc) by microfabricating tissue equivalents with precise spatiotemporal and cellular microenvironments, using cells and Textile polymer based constructs (made up of rapid prototyping, weaving, knitting, nonwoven, Fibre-hydrogel composite).
  3. To design some 'smart' textile architectures for medical applications, such as Hernia mesh, post-surgical adhesion preventive barrier, etc.





  • Tissue Engineering
    • Cartilage & Bone Tissue Engineering
    • Inter-vertebral disc regeneration
    • Establishment of in vitro disease model system
  • Medical Textiles
    • Wound dressings
    • Fibre-Hydrogel composite
    • Hernia Mesh
    • Sutures
  • Polymeric Nano-materials
    • Electrospinning
    • Rapid Prototyping for making novel scaffolds for Tissue engineering
    • Microfluidic chip-based Biosensors
  • Bioreactors
    • Dynamic culture condition for creating specific tissue microenvironment

Research Topics \ Anti-cancer Therapeutics

Major focus of is to understand how 3D tumor architecture can cause lack of immune recognition, downregulate antigen expression. 3D architecture of tumor spheroids can cause hypoxic microenvironment, which regulates TGF-beta signaling pathways and expression of microRNA. Utilizing such insights we are exploring strategies for developing anti-cancer therapeutic options. For example, Peptide Receptor Radionuclide therapy is commonly used for treating neuroendocrine tumors. Nephrotoxicity by high renal radiation dose is major limitation. Synergistic effect of PEG-coated Leutetium dotatate-PLGA nanocapsules and apoptosis-inducing anti-beta-hCG monoclonal antibody caused 80% cytotoxicity, as well as highest tumor-to-kidney ratio (compared to tumor-to-liver and tumor-to-bone ratio) in tumor-inoculated wister rats.


Anti-cancer Therapeutics

Publications

  • Scientific Reports, 5, 2015, doi: 10.1038/srep09650
  • PLoS ONE, 2012, 7(3), e34019
  • Hellenic Journal of Nuclear Medicine, 2012, 15 (2), 108-13