Research

Our current research initiatives are focused on:

  1. Development of engineered tissue constructs (e.g., cartilage and bone-like tissues) to replace diseased or injured organs,

  2. Establishment of simple in vitro disease model system (especially for arthritis, degenerative Intervertebral disc) by microfabricating tissue equivalents with precise spatiotemporal and cellular microenvironments, using cells and Textile polymer based constructs (made up of rapid prototyping, weaving, knitting, nonwoven, Fibre-hydrogel composite).
  3. To design some 'smart' textile architectures for medical applications, such as Hernia mesh, post-surgical adhesion preventive barrier, etc.





  • Tissue Engineering
    • Cartilage & Bone Tissue Engineering
    • Inter-vertebral disc regeneration
    • Establishment of in vitro disease model system
  • Medical Textiles
    • Wound dressings
    • Fibre-Hydrogel composite
    • Hernia Mesh
    • Sutures
  • Polymeric Nano-materials
    • Electrospinning
    • Rapid Prototyping for making novel scaffolds for Tissue engineering
    • Microfluidic chip-based Biosensors
  • Bioreactors
    • Dynamic culture condition for creating specific tissue microenvironment

Research Topics \ Controlling self-assembly of silk protein

We are trying to control secondary conformation of silk fibroin proteins. We have investigated human monocyte and T cell responsiveness of silk based biomaterials having different conformation as well as architecture. Physical characteristics and protein conformations play decisive role in induction of pro-inflammatory responses in monocytes upon stimulation with silk biomaterials.


Controlling self-assembly of silk protein to tailor-made innate and adaptive immune response to the biomaterials

Publications

  • Biomaterials, 2013, 34, 8161-8171
  • Biomacromolecules, 2015, 16(12), 3936-3944